You can use Collections to organize your documents in whatever groupings make sense to you. Documents can be in more than one collection. Look for the New Collection text in the left side menu of Mendeley Reference Manager or Mendeley Web. Name the collection, and then hit Enter to create it.
You can assign tags to each document in your Library and use these tags to help to locate and organize documents.
You can also use the star icon to mark favorite documents, and mark documents as read or unread using the green circle.
In Mendeley Reference Manager or the browser version, you can create notebook pages for typing notes. Notebook pages can be accessed and switched between from any of the citations in your library.