|Historical dates: 1960s|
- 1960: The Frank C. Thompson estate on Big Bend Boulevard near Edgar Road was added to the campus in an exchange of property with the Episcopal Diocese of Missouri. The Thompson house became the home of the Music Department.
- 1961: In September, the Carriage House on the Thompson estate became the art center of the College. The building is now used by the University to house the offices of The Repertory Theatre of St. Louis.
- 1962: The first male students were enrolled in the Fine Arts program.
- 1963: The College School was established as an experimental laboratory for teaching and learning.
- 1964: The first graduate program, a Master of Arts in Teaching (M.A.T.), was instituted with partial support from the Ford and National Science foundations.
- 1964: Men in Fine Arts were allowed to complete their course work at the College and to receive degrees from Webster.
- 1965: Webster's board of directors, then composed entirely of Sisters of Loretto, and the
faculty voted to eliminate general degree requirements.
- 1965: Sister Francetta Barberis, President of Webster College, resigned to take a job in Washington, D.C. She was succeeded by Sister Jacqueline Grennan.
- 1966: The Loretto-Hilton Center for the Performing Arts was completed.
- 1966: Webster College established an M.A.T. program in Kansas City.
- 1967: The Sisters of Loretto transferred ownership of the College to a lay board of directors.
- 1968: The policy of accepting male students was extended to all departments.
- 1968: During the Vietnam War, the College established the VAULT program (Veterans' Accelerated Urban Learning for Teaching) to train Vietnam veterans to teach or assume other professional roles in inner-city schools, primarily at the elementary level.
- 1969: Jacqueline Grennan, President of Webster College, resigned. She was succeeded by Dr. Leigh Gerdine.